Chiyo Sakura is a cheery high school student who is over over heads in love with the naive Umetarou Nozaki. When Chiyo confesses to her lover Nozaki, he presents her an unknown signature, much to her surprise. As it turns out, the stoic adolescent is a well-known shoujo mangaka who goes by the pen name Sakiko Yumeno! Chiyo becomes one of Nozaki's manga assistants as a result of a series of misunderstandings. Throughout the humorous events that follow, she meets several of her eccentric classmates, including her seemingly shameless fellow assistant, Mikoto Mikoshiba, and the "Prince of the School," Yuu Kashima. Gekkan Shoujo Nozaki-kun follows Chiyo as she works to assist Nozaki with his manga, hoping that he would finally recognize her affections.